The talk about Scottish independence has really taken off since the EU referendum, and there's more and more talk about the possibility of a border vote in N'orn Iron. As Gordon Brown said on the radio this morning (I haven't read his piece in the Telegraph yet) the regions outside the M25 have been feeling more and more distant from Westminster and Boris seems to treat these areas with a certain level of distain (the example of him not responding to letters from the Welsh Minister Mark Drakeford, for instance). And during the pandemic there's been as big a separation between the various regions in the UK as there's ever been with, at times, the English being banned for travelling into Wales and/or Scotland as each country had different lockdown rules in place.
The point Brown was making (and he's saying this from a pro-Union stance, I believe) is that Westminster can't take the Union for granted and that to maintain it's integrity, not only would there need to be a positive message campaign to neuter the nationalist movements, but also an idea to reform the House of Lords to more of a regional Senate to allow Wales, Northern Ireland, Scotland, the North, the South West, etc more of a say in Westminster.
But is it too late to preserve the Union in its current state? Although Westminster says the last Scottish Referendum was a "once in a lifetime" vote, it was held before the EU referendum, and one of the points made by Unionists in the leadup to the Scottish vote was that we weren't going to leave the EU. Scotland voted to remain in the EU in 2016, and we left. Northern Ireland is more tricky: they are in a mess post-Brexit, and there's even talk from some Unionists there that they would be better served rejoining with Ireland. The pathway for a border vote there is somewhat easier than that for one for Scottish independence (although Westminster can't prevent an "advisory" referendum in Scotland, nor ignore the results of it: there is a recent precedent of that, IIR...), but even without the Brexit card, the rise of the Catholic (and pro Eire) there as a percentage of the population meant that, eventually, there would be a majority in favour of ceding from the UK.
Personally, I have no issues if Scotland and (potentially) Northern Ireland were to leave the Union. I think the UK would be a lesser place without them, but if many Brexiters keep harping on about "being English" then they cannot in any way object if a Scottish person wanted a seperate Scotland. What I do find interesting is that those who were pro-European Union seem more inclined to support a breakup of the United Kingdom, while those who were keen on us leaving the EU talk about the sanctity of the United Kingdom (which is actually only 99 years old). And, unless the Unionists take Gordon Brown's warning to heart, if there is a referendum vote in the near future in Scotland or Northern Ireland, then Unionists are at risk of making the same mistake the Remainers made leading up to 2016 by focussing on the fears of leaving rather than the benefits of remaining.