The countdown to Leyton Orient
Josh Smith is the referee for the game, last season he issued 81 yellow cards and six reds in 26 games and was last in charge of an Argyle game in August last season when the Greens beat Walsall 3-0 at Home Park in League Two. He will be assisted on Tuesday by Mark Russell and George Byrne while the fourth official is Rob Smith.
Sky Bet have placed Argyle as favourites to win the game at 6/4, an Orient win is ranked at 17/10 and the draw at 90 minutes is on offer at 9/4.
There will be no extra time and if the scores are level at 90 minutes the tie will be decided by penalties.
Leyton Orient have won their first three games of the season; a 2-1 at Forest Green Rovers in the Carabao Cup, a 3-2 home win in the EFL Trophy v the Brighton under-21 team and a 1-0 win away to Oldham in the first League Two game of the season.
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Argyle have played Leyton Orient a total of 58 times; winning 29 games, losing 18 and drawing 11. At Leyton Orient the Greens have won 11, lost 13 and drawn four and have won the last two games at Brisbane Road.
Argyle striker Luke Jephcott will miss the game after picking up a thigh injury in the win against Blackpool on Saturday, midfielder Conor Grant was also injured in that game but is fit to play at Leyton Orient on Tuesday.
Match preview .... Orient club website
Match preview .... Argyle club website
Match programme free .. here