Reuben definitely needs a break, Sheridan alluded to the fact he might get one in his post match interview. Other than that I wouldn't hurry into any changes, unless anyone steps forwards and admits to Shez that a niggle they have could be benefit with rest. It might also be an opportunity to test out some players that haven't had as much game time. Norburn, Harvey, Purrington, Banton and Cox perhaps. Maybe even a formation switch, see if we can fit players into a new system that might prove a vital plan B in the final 3 games.
I'd probably go (sticking with the 5-3-2/3-5-2);
Luke;
Mellor, Nelson, O'Connor (McHugh has his knee all strapped up right?), Hartley (maybe O'Connor in for him instead of McHugh as he's had thigh or groin issues?), THD (or Ben P);
Cox, Norburn, Bobby Reid;
Brunt, Lewi.